DEPARTMENT NAME
Department of Biochemistry

CONTACT DETAILS FOR HEAD OF DEPARTMENT
Prof. Jakub Fichna, PhD, DSc
jakub.fichna@umed.lodz.pl
+48 42 272 57 07

Department of Biochemistry
ul. Mazowiecka 6/8
92-215 Lodz, Poland
www.zakladbiochemii.pl www.zyjmyzdrowiej.umed.pl

TEAM MEMBERS

Head:
Prof. Jakub Fichna, PhD, DSc

Faculty:
Urszula Lewandowska, PhD, DSc; Marta Zielińska, PhD; Maciej Sałaga, PhD PhD

Students:
Katarzyna Owczarek; Krzysztof Siczek; Andrzej Wasilewski; Paula Mosińska; Aleksandra Sobolewska-Włodarczyk; Marcin Włodarczyk; Hubert Zatorski; Adam Fabisiak; Natalia Fabisiak; Julia Krajewska; Aleksandra Tarasiuk; Katarzyna Chojnacka

Interns:
Agata Jarmuż; Jakub Włodarczyk; Agata Binienda

SHORT DESCRIPTION OF RESEARCH ACTIVITY

Aims:

• to understand the pathophysiology of gastrointestinal diseases and the involvement of intrinsic and extrinsic factors (opioid, cannabinoid, melatonin, orphan and other receptors)
• to validate new pharmacological targets for future treatment of IBS and IBD; to translate these results into clinical conditions
• to design and perform pharmacological characterization of novel molecules with therapeutic potential in the gastrointestinal tract

DEPARTMENTAL ACHIEVEMENTS: PROJECTS AND PAPERS

Zielińska, M.;# Fichna, J.;# Bashashati, M.; Habibi, S.; Sibaev, A.; Timmermans, J.-P.; Storr, M. G protein-coupled estrogen receptor (GPER) and estrogen receptor ligands regulate colonic motility and visceral pain. #Equal contribution. Neurogastroenterol Motil. 2017; 29, epub ahead of print

Wasilewski, A.; Lewandowska, U.; Mosinska, P.; Watala, C.; Storr, M.; Fichna, J.; Venkatesan, T. Cannabinoid receptor type 1 (CNR1) and mu opioid receptor (MOR) polymorphisms are associated with cyclic vomiting syndrome. Am. J. Gastroenterol. 2017; 112: 933-939.

Sałaga, M.; Mokrowiecka, A.; Jacenik, D.; Cygankiewicz, A.I.; Małecka-Panas, E.; Kordek, R.; Krajewska, W.M.; Sobocinska, M.K.; Kamysz, E.; Fichna, J. Systemic administration of sialorphin attenuates experimental colitis in mice via interaction with mu and kappa opioid receptors. J Crohn’s Colitis 2017; 11: 988-998.