Immunological and metabolic changes in depression and schizophrenia. Biomarkers and pathogenesis of delirium after cardiac surgery. Clinical, environmental and genetic factors predisposing to remission of first onset psychosis. The use of bifrontal electrotherapy in patients with a diagnosis of treatment-resistant schizophrenia. ADHD in adults.

The clinic carries research and development activities in the elderly, including complex medical problems, prevention of diseases of the elderly, diagnostic, therapeutic and consultative activities in the field of diseases of elderly people.

Our department is pursuing therapeutic, teaching and scientific activities in the fields of allergy and clinical immunology. The research interests of the team focus on the epidemiology and development of allergic disease.

Research areas: asthma with aspirin hypersensitivity, severe steroid-dependent asthma, epidemiology of allergic diseases, specific immunotherapy, drug hypersensitivity, glucocorticoid receptor gene polymorphisms, atopic dermatitis, chronic urticaria, allergic rhinitis

The Department uses modern molecular biology techniques as well as a number of self-designed authorial tests including the comet, BER, NER and HRR assays. In addition, cell cultures are performed using various cell lines. Research areas include the molecular basis of neurodegenerative disorders such as Alzheimer’s disease, POAG, MS, and various types of cancer.

Research in the Laboratory of Bioanalysis is focused on the biocompatibility and bioactivity assessment of new compounds and natural substances using in vitro methods (human blood and cell culture models). Research in the Laboratory of Radiopharmacy is focused on the use of new radiopharmaceuticals as tools for diagnosis of Alzheimer’s disease and multifunctional agents for its treatment.

Primary Immunodeficiencies, PID, SCID, Lymphoproliferative Syndrome, ALPS, Neutropenia, SCN, HLH, FHL, Next Generation Sequencing, NGS, SNP-array ALL, epigenetics, histones, chromatin, minimal residual disease, MRD Tuberous sclerosis, pathogenesis, signalling pathway, microRNA, metabolome, Genetic determinants of haemophilia comorbidities and treatment, factor VIII inhibitor, factor VIII pharmacokinetics, Monogenic diabetes, Wolfram syndrome, new technologies, artificial pancreas, education

Research area: investigation of the molecular mechanisms involved in colorectal cancer progression, including epithelial and endothelial to mesenchymal transitions (EMT and EndMT); characterization of the novel pathways engaged in the cytoskeleton reorganization (involving such proteins as MRTF, beta-tubulins and filamin A), which lead to the increased cell migration and invasiveness and analysis of the mechanisms regulating endothelial cell senescence that underlie pathologies of the cardiovascular system.

The projects include the evaluation of the association of DNA repair XRCC3 C722T and RAD51 G135C gene polymorphisms and the risk of head and neck cancers. Another research project involves research on inverted papillomas as a unique group of locally aggressive, benign tumors within the nasal cavity and paranasal sinuses.

Research area: variation and abnormalities of the cardio-vascular system, anatomical variations of the musculo-skeletal system, protective and predisposing morphological factors in suprascapular neuropathy, study of vascularisation of the animals testis, kidneys and hears and morphological studies based on radiological investigations.

Research interests focus on the investigation of molecular mechanisms of metabolic diseases (Gestational Diabetes Mellitus, GDM), antioxidant properties of plant extracts, especially evening primrose extract. Another area of ​interest is the use of metabolomics to evaluate the lipid profile of erythrocyte cell membranes of women diagnosed with GDM. The research is conducted in cooperation with Carl Ferris from ISOF CNR in Bologna.

Research area: identification of diagnostic markers involved in the pathogenesis of selected lifestyle diseases, evaluation of drug-drug interactions for cardiovascular therapies, therapeutic activity of novel agents in pulmonary hypertension, experimental studies on animal models, biopharmaceutical assessment of medical products and devices (in vitro, in vivo).

Main directions of scientific interest: pathogenesis of cancerous lesions in the testis, hormonal control of spermatogenesis, endocrine aspects of sexual differentiation, research on aging processes of men, causes of fertility disorders in men, improving diagnosis and treatment of male genital disorder, the impact of environmental factors on developmental disorders and the functioning of the male reproductive system.

A key subject of our scientific efforts concerns the bidirectional liaisons between mental state, psychosocial conditions and health and disease in a bio-psycho-social research paradigm. We are particularly interested in the interface between clinical medicine and Psychology.

Research area: pathomechanism of glomerulopathies, immunopathology of glomerulopathies, the diagnosis of glomerulonephritis by immmunofluorescence and electron microscopy, IgA nephropathy, morphologic and immunological predictive markers, nephrotic syndrome and neoplasia, morphologic and immunohistochemical predictive markers in head and neck cancers, lymphocytes, macrophages and dendritic cells in tumour microenvironment, epithelial to mesenchymal transition in malignant neoplasm.

The Clinic team conducts Cardiology classes with medical and paramedic students. It also gives integrated curriculum classes and two elective classes: ‘I am not afraid of ECGs’ and ‘Difficult patients in Cardiology’. Students may also perform research, write diploma theses and PhD studies. The scientific interests of the team are focused primarily on the contemporary problems of intensive and acute cardiac care.